Tobacco use is the leading cause of preventable mortality and morbidity in the United States and is responsible for over 400,000 deaths each year. Smoking causes about 90% of all lung cancer deaths in the United States. Those who smoke regularly are more likely than nonsmokers to develop heart disease, stroke, and lung cancer. About 50% of smokers develop chronic obstructive pulmonary disease. This new Rural Tobacco Control and Prevention Toolkit from the Rural Health Information Hub provides information, strategies, and resources to help rural communities implement tobacco control and prevention programs. Divided into seven modules, the kit includes program models, implementation and evaluation plans, ideas for dissemination and more.