The NIH Big Data to Knowledge program has announced the 2017 spring semester of The BD2K Guide to the Fundamentals of Data Science, a series of online lectures given by experts from across the country covering a range of diverse topics in data science. This course is an introductory overview that assumes no prior knowledge or understanding of data science. The series runs through May, meeting weekly on Fridays at 9:00-10:00am Pacific Time. No registration is required. The first semester of the series in fall 2016 covered data management and data representation. The new semester will cover computing, data modeling, and overarching topics. Archives of previous presentations are available. This is a joint effort of the BD2K Training Coordinating Center, the BD2K Centers Coordination Center, and the NIH Office of the Associate Director of Data Science.