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Is a Missing Protein the Cause of Eosinophilic Esophagitis?

Posted by on June 14th, 2018

Picture of EoE

“Illustration of an Eosinophil” via nih.gov, June 6, 2018, Public Domain.

A National Institute of Health funded study finds that the absence of SPINK7 in cells lining the esophagus may be impacting those who have eosinophilic esophagitis (EoE). The lack of this protein may cause inflammation and tissue damage.

EoE is a chronic disease of the esophagus where white blood cells build up causing tissue damage and inflammation. EoE is more prevalent in men than women and typically affects those under the age of 50. This is a relatively new disease and ongoing studies could impact diagnosis and treatment in the future.

The discovery that SPINK7 is found in those with a healthy esophagus but absent in those with EoE could lead to a treatment that could reverse some of the damage and inflammation associated with the disease. Currently treatment consists of managing symptoms through diet, exercise, and even surgical intervention.

Read more about the NIH Study.

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Funded under cooperative agreement number UG4LM012345 with the University of North Texas Health Science Center - Gibson D. Lewis Library, and awarded by the DHHS, NIH, National Library of Medicine.

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